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PEA guards against bacterial an infection by way of innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA at a dose of 0.1 mg/kg overall body fat prolonged survival charge and reduced neuro-inflammation within an aged murine bacterial meningitis design, within the absence of antibiotics [42].?acylethanolamines (NAEs),

Of note is the fact, resulting from PEA’s high lipophilicity, micronized or extremely-micronized formulations are believed to become extra effortlessly absorbable, with more favorable pharmacokinetics and greater efficacy. Although There is certainly some proof supporting this concept, there remains to be no evidence of your superiority of micron